Master Cancer

JUSTINE LENGRAND 2014-2015

Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.

Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, Lengrand J, Deshpande V, Selig MK, Ferrone CR, Settleman J, Stephanopoulos G, Dyson NJ, Zoncu R, Ramaswamy S, Haas W, Bardeesy N.

Nature. 2015 Aug 20;524(7565):361-5. doi: 10.1038/nature14587. Epub 2015 Jul 13.

Nerve growth factor and proNGF simultaneously promote symmetric self-renewal, quiescence, and epithelial to mesenchymal transition to enlarge the breast cancer stem cell compartment.

Tomellini E, Touil Y, Lagadec C, Julien S, Ostyn P, Ziental-Gelus N, Meignan S, Lengrand J, Adriaenssens E, Polakowska R, Le Bourhis X.

Stem Cells. 2015 Feb;33(2):342-53. doi: 10.1002/stem.1849.

MARJORIE LAPOUGE 2014-2015

YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression. Fitamant J¹, Kottakis F¹, Benhamouche S², Tian HS³, Chuvin N³, Parachoniak CA¹, Nagle JM³, Perera RM¹, Lapouge M³, Deshpande V⁴, Zhu AX⁵, Lai A⁶, Min B⁶, Hoshida Y⁷, Avruch J⁸, Sia D⁹, Campreciós G⁷, McClatchey AI⁴, Llovet JM¹⁰, Morrissey D⁶, Raj L⁶, Bardeesy N¹¹.Cell Rep. 2015 Mar 10. pii: S2211-1247(15)00173-4. doi: 10.1016/j.celrep.2015.02.027

CHARLENE NIOGRET 2014-2015

The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity.

Castro W, Chelbi ST, Niogret C, Ramon-Barros C, Welten SPM, Osterheld K, Wang H, Rota G, Morgado L, Vivier E, Raeber ME, Boyman O, Delorenzi M, Barras D, Ho PC, Oxenius A, Guarda G.

Nat Immunol. 2018 Aug;19(8):809-820. doi: 10.1038/s41590-018-0144-9. Epub 2018 Jul 2.

Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo.

Rota G, Niogret C, Dang AT, Barros CR, Fonta NP, Alfei F, Morgado L, Zehn D, Birchmeier W, Vivier E, Guarda G.

Cell Rep. 2018 Apr 3;23(1):39-49. doi: 10.1016/j.celrep.2018.03.026.

Unexpected cross-reactivity of anti-cathepsin B antibodies leads to uncertainties regarding the mechanism of action of anti-CD20 monoclonal antibody GA101.

Chien WW, Niogret C, Jugé R, Lionnard L, Cornut-Thibaut A, Kucharczak J, Savina A, Salles G, Aouacheria A.

Leuk Res. 2017 Apr;55:41-48. doi: 10.1016/j.leukres.2017.01.010. Epub 2017 Jan 18.

OCTAVIA CADASSOU 2014-2015

Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer.

Delaney JR, Patel CB, Willis KM, Haghighiabyaneh M, Axelrod J, Tancioni I, Lu D, Bapat J, Young S, Cadassou O, Bartakova A, Sheth P, Haft C, Hui S, Saenz C, Schlaepfer DD, Harismendy O, Stupack DG.

Nat Commun. 2017 Feb 15;8:14423. doi: 10.1038/ncomms14423.

LUCAS BARTHLY 2015-2016

Mature IgM-expressing plasma cells sense antigen and develop competence for cytokine production upon antigenic challenge.

Blanc P, Moro-Sibilot L, Barthly L, Jagot F, This S, de Bernard S, Buffat L, Dussurgey S, Colisson R, Hobeika E, Fest T, Taillardet M, Thaunat O, Sicard A, Mondière P, Genestier L, Nutt SL, Defrance T.

Nat Commun. 2016 Dec 7;7:13600. doi: 10.1038/ncomms13600.

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma.

Zaretsky JM, Garcia-Diaz A, Shin DS, Escuin-Ordinas H, Hugo W, Hu-Lieskovan S, Torrejon DY, Abril-Rodriguez G, Sandoval S, Barthly L, Saco J, Homet Moreno B, Mezzadra R, Chmielowski B, Ruchalski K, Shintaku IP, Sanchez PJ, Puig-Saus C, Cherry G, Seja E, Kong X, Pang J, Berent-Maoz B, Comin-Anduix B, Graeber TG, Tumeh PC, Schumacher TN, Lo RS, Ribas A.

N Engl J Med. 2016 Sep 1;375(9):819-29. doi: 10.1056/NEJMoa1604958. Epub 2016 Jul 13.

AHLIMA ROUMANE 2015-2016

LKB1 loss links serine metabolism to DNA methylation and tumorigenesis. Kottakis F^1,2,3, Nicolay BN^1,3, Roumane A^1,2,3, Karnik R^4,5,6, Gu H^4,5,6, Nagle JM^1,2,3, Boukhali M^1,3, Hayward MC⁷, Li YY^8,9, Chen T^8,9,10, Liesa M^11,12, Hammerman PS^8,9,13, Wong KK^8,9,10, Hayes DN⁷, Shirihai OS^11,12, Dyson NJ^1,3, Haas W^1,3, Meissner A^4,5,6, Bardeesy N^1,2,3. Nature. 2016 Nov 17;539(7629):390-395. doi: 10.1038/nature20132. Epub 2016 Oct 31.

Caspase-independent cell death does not elicit a proliferative response in melanoma cancer cells. Roumane A¹, Berthenet K^1,2, El Fassi C¹, Ichim G^3,4. BMC Cell Biol. 2018 Jul 4;19(1):11. doi: 10.1186/s12860-018-0164-1.

IULIA REVENCO 2016-2017

Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Patra KC^1,2, Kato Y¹, Mizukami Y^1,3,4, Widholz S¹, Boukhali M¹, Revenco I¹, Grossman EA⁵, Ji F^6,7, Sadreyev RI^1,8,9, Liss AS¹, Screaton RA^10,11, Sakamoto K^12,13, Ryan DP^1,2, Mino-Kenudson M^1,8,9, Castillo CF^1,14,15, Nomura DK⁵, Haas W¹, Bardeesy N^16,17.

Nat Cell Biol. 2018 Jul;20(7):811-822. doi: 10.1038/s41556-018-0122-3. Epub 2018 Jun 25.

ALINE RENOULT 2016-2017

Dysregulation of the MiR-449b target TGFBI alters the TGFβ pathway to induce cisplatin resistance in nasopharyngeal carcinoma. Bissey PA¹, Law JH², Bruce JP¹, Shi W¹, Renoult A³, Chua MLK^1,4,5,6, Yip KW¹, Liu FF^7,8,9. Oncogenesis. 2018 May 22;7(5):40. doi: 10.1038/s41389-018-0050-x.

KARINE LEVEQUE 2016-2017

GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.

Tanikawa C, Kamatani Y, Takahashi A, Momozawa Y, Leveque K, Nagayama S, Mimori K, Mori M, Ishii H, Inazawa J, Yasuda J, Tsuboi A, Shimizu A, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Naito M, Wakai K, Koyama T, Takezaki T, Yuji K, Murakami Y, Nakamura Y, Kubo M, Matsuda K.

Carcinogenesis. 2018 May 3;39(5):652-660. doi: 10.1093/carcin/bgy026.

ANTHONY STEPHANOU 2016-2017

Predominance of regorafenib over sorafenib: Restoration of membrane-bound MICA in hepatocellular carcinoma cells.

Arai J, Goto K, Stephanou A, Tanoue Y, Ito S, Muroyama R, Matsubara Y, Nakagawa R, Morimoto S, Kaise Y, Lim LA, Yoshida H, Kato N.

J Gastroenterol Hepatol. 2018 May;33(5):1075-1081. doi: 10.1111/jgh.14029. Epub 2018 Feb 6.

PAULINE GENTAZ 2017-2018

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Bird TG^1,2,3, Müller M⁴, Boulter L^2,5, Vincent DF⁴, Ridgway RA⁴, Lopez-Guadamillas E⁶, Lu WY², Jamieson T⁴, Govaere O⁷, Campbell AD⁴, Ferreira-Gonzalez S², Cole AM⁴, Hay T⁸, Simpson KJ², Clark W⁴, Hedley A⁴, Clarke M⁹, Gentaz P⁴, Nixon C⁴, Bryce S⁴, Kiourtis C^4,10, Sprangers J⁴, Nibbs RJB⁹, Van Rooijen N¹¹, Bartholin L¹², McGreal SR¹³, Apte U¹³, Barry ST¹⁴, Iredale JP^3,15, Clarke AR¹⁶, Serrano M^6,17, Roskams TA⁷, Sansom OJ^4,10, Forbes SJ^2,3.

Sci Transl Med. 2018 Aug 15;10(454). pii: eaan1230. doi: 10.1126/scitranslmed.aan1230

2018-2019

L'alimentation, un allié pendant le traitement - Michel KAHI, Célia MARUEJOULS, Valentin THEVIN

2017-2018

 Projet C.R.A.C. - Marion Muller, Richard MIALLOT, Benjamin ESTAVOYER

Site Web

Dis Maman pourquoi t'es malade - Fabiana IZAGUIRRE, Fanny BAILLAT, Caroline FEZELOT

Page Facebook